BACE : Lead Target for Orchestrated Therapy of Alzheimer's Disease (Hardcover)

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BACE inhibitors and their use in the treatment of Alzheimer's Disease

BACE (?-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery.

This book details the story of the discovery of BACE and its role in AD and comprehensively discusses:

  • The development of BACE inhibitors as therapeutics for Alzheimer's disease

  • The research that led to the identification of BACE

  • New BACE inhibitors currently being clinically tested

  • ADME (absorption, distribution, metabolism, excretion) and clinical trial design?topics not addressed in current field literature

  • Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimer's drug discovery

  • Other approaches to BACE inhibition based on interaction with the precursor protein APP

By enhancing the reader's understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimer's research?and inspire new approaches to treatment of AD.


Publisher John Wiley & Sons Inc
Mfg Part# 9780470293423
SKU 212447529
Format Hardcover
ISBN10 047029342X
Release Date 3/1/2010
Product Attributes
eBooks Kobo
Book Format Hardcover
Number of Pages 0250
Publisher John Wiley & Sons
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