My optometrist recommended this and Aquify, and having used several brands, I found Opti-Free to be the best. I've used it several years with no problems. It seems to clean my contacts effectively, and leaves them feeling very moist. That seems weird to say, but I have noticed the difference between this and others, as my contacts retain moisture and are more comfortable after using this.
I also like the Opti-Free Express, but I think Replenish leaves my eyes feeling better.
Retains moisture for enhanced comfort. No. 1 doctor recommended (Survey of 300 optometrists, Harris Interactive, December 2006). Reconditions lenses to retain surface moisture for enhanced comfort. Removes protein daily. No rub. Cleans; Reconditions; Rinses; Disinfects; Stores. For silicone hydrogel and soft contact lenses. Sterile. Cleaning: Proven gentle cleaning agents remove daily protein deposits so that lenses are fresh and comfortable all day long. Comfort: Contains a proprietary dual action reconditioning system Tearglyde that is proven to retain moisture on the lens surface throughout the day. Compatible Disinfection: Enhanced disinfection formula (Aldox and Polyquad) that is compatible with silicone hydrogel and soft contact lenses. Kills bacteria (germs) that can cause eye infections. Opti-Free Replenish Multi-Purpose Disinfecting Solution with Tearglyde Reconditioning System: Promotes: Lens cleanliness; Wettability; Lens surface moisture; Comfort; Clear vision. Reduces: Protein build-up; Lens deposits; Discomfort; Appearance of redness. Opti-Free Replenish Multi-Purpose Disinfecting Solution is a proprietary formula that is specially designed to recondition your silicon hydrogel and other soft contact lenses so that your eyes feel fresh and moist throughout the lens wear day. Long lasting reconditioning agents work to keep your lenses clean and comfortable. Opti-Free Replenish Multi-Purpose Disinfecting Solution is proven to retain moisture on the surface of lenses throughout the lens wearing day - everyday. These ingredients are only found in Alcons lens care products. This patented formula is not sold under any other name. Do not change solutions without consulting your eye care professional.