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Highly pathogenic avian influenza (HPAI) represents a threat to poultry industries worldwide and to people's livelihoods, and a potential threat to human health. The international community has vested interest in minimizing the spread of this disease. Countries may be under threat of introduction of avian influenza through exposure of poultry to wild birds, especially waterfowl. They may also be at risk from introduction of infected or contaminated poultry, poultry products or fomites. FAO and the World Organization for Animal Health have prepared this manual to help national animal authorities and other stakeholders prepare for a possible incursion of HPAI, detect diseases as soon as possible and respond as rapidly as possible to contain the disease. The manual offer practical advice on disease identification, pathology and diagnosis; detection, response and control strategies; and biosecurity measures to prevent outbreaks. It is an invaluable source of useful information for anyone involved in poultry-keeping and animal health practices.