The Adam Family of Proteases (Hardcover)

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Product Overview

The ADAM Family of Proteases provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for some time, it is only in recent years through advances in genome sequencing that the large size of this family of zinc metalloproteases has become apparent. These proteins have multiple domains including a protease domain and a disintegrin domain. A branch of the family, called ADAMTS, also have thrombospondin-like motifs. The role of ADAMs and ADAMTS members in a diversity of biological processes is gradually coming to light. For example, some ADAMs have critical roles in the ectodomain shedding of membrane proteins including tumour necrosis factor-a, the cell signalling molecule Notch and the Alzheimer ''s amyloid precursor protein. Other ADAM and ADAMTS family members have key roles to play in sperm function and fertility, collagen processing, development, cardiac hypertrophy and arthritis.

Specifications

Publisher Springer Verlag
Mfg Part# 9780387251493
SKU 202149315
Format Hardcover
ISBN10 0387251499
Release Date 4/10/2007
Product Attributes
Book Format Hardcover
Number of Pages 0344
Publisher Springer
Series Part 4
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$300.70 + $2.75 shipping
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