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GPCR Molecular Pharmacology and Drug Targeting : Shifting Paradigms and New Directions (Hardcover)

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Product Overview

The focus of this book, G protein-coupled receptors (GPCRs) are a large protein family of transmembrane proteins that sense molecules outside the cell and relay the information, thus initiating cellular responses. When this molecular process breaks down, GPCRs become the culprit of many diseases, making them the target of nearly half of all modern medicinal drugs.

GPCR Molecular Pharmacology and Drug Targeting examines the complex inner workings of these proteins by balancing basic research concepts with practical aspects relevant to drug discovery. Throughout, it answers key questions surrounding research into GPCR function---how they get activated; how they signal across the cell membrane; how they couple to intracellular signaling partners; how they communicate to each other as well as to other receptors and other membrane proteins; and how their mutations lead to disease. At the same time, it explores the many ways in which the receptors can be screened at each of these critical steps for compounds that modulate their action.

GPCR Molecular Pharmacology and Drug Targeting provides the historical groundwork and acts as an essential resource for any scientists working with this important and therapeutically relevant family. The in-depth discussions on recent findings and extensive coverage of screening approaches provide the necessary framework for encouraging exploration into malfunctioning GPCRs and identifying novel medicinal solutions.


Publisher John Wiley & Sons Inc
Mfg Part# 9780470307786
SKU 213830876
Format Hardcover
ISBN10 0470307781
Release Date 4/2/2012
Product Attributes
eBooks Kobo
Book Format Hardcover
Number of Pages 0520
Publisher John Wiley & Sons
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